Description
Product Characteristics:
Aliases: OTTHUMP00000004041 antibody, OTTMUSP00000010350 antibody, PAF R antibody, PAF receptor antibody, PAF-R antibody, PAFr antibody, Platelet activating factor receptor antibody, Platelet-activating factor receptor antibody, PTAFR antibody, PTAFR_HUMAN antibody, RP23-470B20.1 antibody
Target Information: This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]